Drug-induced dry eye: Knowing your medications

November 27, 2019

From antiacne medications to antihistamines, many drugs can contribute to the development of dry eye syndrome or be the causes of dry eye. Let's look at the most common ones1-5:

Contraceptive pills

Estrogen may affect the production of the aqueous components in your tear film and therefore dry out your eyes. If you have DED, consult with your gynecologist when using birth control pills or if on hormone replacement therapy for menopause.1-5

Drug-induced dry eye: Contraceptive pills
References
  1. Fraunfelder, Frederick T, et al. The role of medications in causing dry eye. Journal of ophthalmology vol. 2012 (2012): 285851. doi:10.1155/2012/285851
  2. J. Daniel Nelson, et al. Non-hormonal Systemic Medications and Dry Eye. Ocul Surf. 2011 Oct;9(4):212-26. https://doi.org/10.1016/S1542-0124(11)70034-9
  3. Jaanus SD. Ocular side effects of selected systemic drugs. Optom Clin. 1992;2(4):73-96. https://www.ncbi.nlm.nih.gov/pubmed/1363080
  4. Junping Li, Ramesh C. Tripathi, Brenda J. Tripathi. Drug-induced ocular disorders. Drug Saf. 2008;31(2):127-41. https://www.ncbi.nlm.nih.gov/pubmed/18217789
  5. Facts About Dry Eye. The national eye institute. https://nei.nih.gov/health/dryeye/dryeye. Last accessed August 25, 2019.

Antihypertensive drugs

Antihypertensive drugs that are classified as beta blockers can reduce tear production and can lead to symptoms of dry eye.1-5

Drug-induced dry eye: Antihypertensive drugs
References
  1. Fraunfelder, Frederick T, et al. The role of medications in causing dry eye. Journal of ophthalmology vol. 2012 (2012): 285851. doi:10.1155/2012/285851
  2. J. Daniel Nelson, et al. Non-hormonal Systemic Medications and Dry Eye. Ocul Surf. 2011 Oct;9(4):212-26. https://doi.org/10.1016/S1542-0124(11)70034-9
  3. Jaanus SD. Ocular side effects of selected systemic drugs. Optom Clin. 1992;2(4):73-96. https://www.ncbi.nlm.nih.gov/pubmed/1363080
  4. Junping Li, Ramesh C. Tripathi, Brenda J. Tripathi. Drug-induced ocular disorders. Drug Saf. 2008;31(2):127-41. https://www.ncbi.nlm.nih.gov/pubmed/18217789
  5. Facts About Dry Eye. The national eye institute. https://nei.nih.gov/health/dryeye/dryeye. Last accessed August 25, 2019.

Antihistamines

They block your body's response to allergy triggers and prevent symptoms like watery eyes or runny nose, but they also restrict the lacrimal glands to a point, that there are not enough tears for lubricating your eyes.1-5

Drug-induced dry eye: Antihistamines
References
  1. Fraunfelder, Frederick T, et al. The role of medications in causing dry eye. Journal of ophthalmology vol. 2012 (2012): 285851. doi:10.1155/2012/285851
  2. J. Daniel Nelson, et al. Non-hormonal Systemic Medications and Dry Eye. Ocul Surf. 2011 Oct;9(4):212-26. https://doi.org/10.1016/S1542-0124(11)70034-9
  3. Jaanus SD. Ocular side effects of selected systemic drugs. Optom Clin. 1992;2(4):73-96. https://www.ncbi.nlm.nih.gov/pubmed/1363080
  4. Junping Li, Ramesh C. Tripathi, Brenda J. Tripathi. Drug-induced ocular disorders. Drug Saf. 2008;31(2):127-41. https://www.ncbi.nlm.nih.gov/pubmed/18217789
  5. Facts About Dry Eye. The national eye institute. https://nei.nih.gov/health/dryeye/dryeye. Last accessed August 25, 2019.

Nasal decongestants

To get rid of stuffy nose in case of cold or allergy, you can rely on a decongestant, because it reduces the swelling in the blood vessels of your nose and increases the airflow. But unfortunately, it may reduce the amount of your tears, too.1-5

Drug-induced dry eye: Nasal decongestants
References
  1. Fraunfelder, Frederick T, et al. The role of medications in causing dry eye. Journal of ophthalmology vol. 2012 (2012): 285851. doi:10.1155/2012/285851
  2. J. Daniel Nelson, et al. Non-hormonal Systemic Medications and Dry Eye. Ocul Surf. 2011 Oct;9(4):212-26. https://doi.org/10.1016/S1542-0124(11)70034-9
  3. Jaanus SD. Ocular side effects of selected systemic drugs. Optom Clin. 1992;2(4):73-96. https://www.ncbi.nlm.nih.gov/pubmed/1363080
  4. Junping Li, Ramesh C. Tripathi, Brenda J. Tripathi. Drug-induced ocular disorders. Drug Saf. 2008;31(2):127-41. https://www.ncbi.nlm.nih.gov/pubmed/18217789
  5. Facts About Dry Eye. The national eye institute. https://nei.nih.gov/health/dryeye/dryeye. Last accessed August 25, 2019.

Antidepressants

Anti-anxiety medications and tricyclic antidepressants stop the transfer of signals which activate the glands in your body. These can also affect the lacrimal glands and your eyes produce fewer tears consequently.1-5

Drug-induced dry eye: Antidepressants
References
  1. Fraunfelder, Frederick T, et al. The role of medications in causing dry eye. Journal of ophthalmology vol. 2012 (2012): 285851. doi:10.1155/2012/285851
  2. J. Daniel Nelson, et al. Non-hormonal Systemic Medications and Dry Eye. Ocul Surf. 2011 Oct;9(4):212-26. https://doi.org/10.1016/S1542-0124(11)70034-9
  3. Jaanus SD. Ocular side effects of selected systemic drugs. Optom Clin. 1992;2(4):73-96. https://www.ncbi.nlm.nih.gov/pubmed/1363080
  4. Junping Li, Ramesh C. Tripathi, Brenda J. Tripathi. Drug-induced ocular disorders. Drug Saf. 2008;31(2):127-41. https://www.ncbi.nlm.nih.gov/pubmed/18217789
  5. Facts About Dry Eye. The national eye institute. https://nei.nih.gov/health/dryeye/dryeye. Last accessed August 25, 2019.

Pain relievers

If you use OTC pain medications like ibuprofen and acetaminophen (paracetamol), at especially high doses, you may experience dry eye symptoms.1-5

Drug-induced dry eye: Pain relievers
References
  1. Fraunfelder, Frederick T, et al. The role of medications in causing dry eye. Journal of ophthalmology vol. 2012 (2012): 285851. doi:10.1155/2012/285851
  2. J. Daniel Nelson, et al. Non-hormonal Systemic Medications and Dry Eye. Ocul Surf. 2011 Oct;9(4):212-26. https://doi.org/10.1016/S1542-0124(11)70034-9
  3. Jaanus SD. Ocular side effects of selected systemic drugs. Optom Clin. 1992;2(4):73-96. https://www.ncbi.nlm.nih.gov/pubmed/1363080
  4. Junping Li, Ramesh C. Tripathi, Brenda J. Tripathi. Drug-induced ocular disorders. Drug Saf. 2008;31(2):127-41. https://www.ncbi.nlm.nih.gov/pubmed/18217789
  5. Facts About Dry Eye. The national eye institute. https://nei.nih.gov/health/dryeye/dryeye. Last accessed August 25, 2019.

Antiacne medication

If you have severe acne, your doctor may prescribe isotretinoin, a derivative of vitamin A which reduces the amount of oils produced by your skin. As a side effect, it impacts the production of the lipid layer of your tear film, leading to tear film instability and increased water evaporation, which result in dry eye.1-5

Drug-induced dry eye: Antiacne medication
References
  1. Fraunfelder, Frederick T, et al. The role of medications in causing dry eye. Journal of ophthalmology vol. 2012 (2012): 285851. doi:10.1155/2012/285851
  2. J. Daniel Nelson, et al. Non-hormonal Systemic Medications and Dry Eye. Ocul Surf. 2011 Oct;9(4):212-26. https://doi.org/10.1016/S1542-0124(11)70034-9
  3. Jaanus SD. Ocular side effects of selected systemic drugs. Optom Clin. 1992;2(4):73-96. https://www.ncbi.nlm.nih.gov/pubmed/1363080
  4. Junping Li, Ramesh C. Tripathi, Brenda J. Tripathi. Drug-induced ocular disorders. Drug Saf. 2008;31(2):127-41. https://www.ncbi.nlm.nih.gov/pubmed/18217789
  5. Facts About Dry Eye. The national eye institute. https://nei.nih.gov/health/dryeye/dryeye. Last accessed August 25, 2019.

When you think your medications may link to your dry eye symptoms, don’t stop taking them and discuss with your doctor for alternative treatments. In most cases, drug-induced dry eye will disappear after the medication is discontinued, but it might take several weeks or even months.

Detect dry eye
 
Let’s quickly assess your symptoms using the 
Five‐item Dry Eye Questionnaire (DEQ-5).
START NOW
 
This quick test is not a medical evaluation and does not replace a visit to an eye care professional who can take decisions on medical treatment, diagnosis, or prescription.

관련 게시물

Detect dry eye
 
Let’s quickly assess your symptoms using the 
Five‐item Dry Eye Questionnaire (DEQ-5).
START NOW
 
This quick test is not a medical evaluation and does not replace a visit to an eye care professional who can take decisions on medical treatment, diagnosis, or prescription.